Tempus Immune Profile Score (IPS)

Understand immune checkpoint inhibitor (ICI) treatment response

IPS is an AI-developed algorithm providing prognostic insights into real-world overall survival (rwOS) outcomes for ICI treatment in metastatic solid tumors.

The information on this page is intended for life sciences partners and focuses on research and development applications. If you would like to learn more about the clinical applications, click here.

Refine IO biomarker detection with IPS

Despite advancements in biomarker testing, the need for more sensitive and generalizable biomarkers to predict ICI treatment outcomes still remains. The development of reliable predictors has been hindered by limited access to multi-omic testing and substantial validation cohorts.

IPS helps address these challenges as a DNA- and RNA-based molecular signature that demonstrates prognostic utility in an overall pan-cancer cohort of metastatic solid tumor patients receiving ICI-based regimens.

IPS provides an “Immune Profile Score” ranging from 0 to 100 and classifies patients into two groups*

*Note: Some patients will have indeterminate results. This group was excluded from the validation study due to analytical precision concerns, and we cannot draw any conclusions about their outcomes.

Download the Immune Profile Score (IPS) Overview

IPS-High: Indicates longer rwOS in patients receiving ICI-based regimens.
IPS-Low: Indicates shorter rwOS in patients receiving ICI-based regimens.

OUR SCIENCE

Clinical validation of a novel multi-omic algorithm for stratifying outcomes in a real-world cohort of metastatic solid cancer patients treated with immune checkpoint inhibitors

A prospective-retrospective validation in 1,519 patients demonstrated strong stratification of overall survival (OS) (hazard ratio [HR]=0.45 [0.41-0.57]) in the overall cohort, showing significantly longer OS in IPS-High patients.

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Discover the advantages of IPS

Comprehensive analysis

IPS combines DNA and RNA biomarkers for a robust prognostic score.

Pan-cancer applicability

Applicable to a wide range of solid tumors, supporting broad research applications.

Enhanced stratification

IPS aids in identifying patient populations who may respond favorably to ICI therapies.

Research-ready

IPS can be added to concurrent Tempus xT and xR test orders without requiring additional tissue samples or wet lab assays.

Data-driven

Validated in 1,500+ pan-cancer patients, ensuring the reliability and robustness of the IPS algorithm.

Strong partnership potential

Develop IPS as a companion diagnostic (CDx) for existing or novel therapies and leverage our network of 6,500+ oncologists to help drive clinical adoption.

LIFE SCIENCE RESEARCH APPLICATIONS

IPS offers robust support for life sciences research, providing actionable insights in various applications.

Label Expansion Identify potential patient populations who might benefit from ICI treatments beyond their current labeling.
Novel ICI Combinations Target populations with suboptimal responses to standard ICIs who may benefit from novel combination therapies.
Trial Design Enhance patient selection and stratification in clinical trials, enabling more effective study designs.

PARTNERSHIP OPPORTUNITIES

Tailored access to IPS

We offer a full spectrum of capabilities—from data licensing to validation to adoption—ensuring support for your research needs.

Sequencing
Access IPS results through sequencing of retrospective tissue samples with concurrent Tempus xT and xR orders.
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Multimodal Data
Analyze IPS results across de-identified patient records that incorporate clinical, molecular, and imaging modalities through flexible licensing solutions.
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Companion Diagnostics
Partner with us to develop IPS as a CDx for an existing or novel therapy.
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Partner with us

With a broad range of laboratory services and data analysis capabilities that support immunotherapy development, Tempus is your comprehensive precision medicine partner.