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Tempus IO™

A comprehensive immunotherapy platform that provides actionable and cutting-edge services for life sciences partners advancing IO therapies, including antibody-drug conjugates (ADCs), TCR therapies, and immune checkpoint inhibitors (ICIs).

An all-in-one biomarker platform

Comprehensive real-world data (RWD)

~99% of whole transcriptome profiles contain at least one IO biomarker

Robust suite of IO biomarkers

10+ IO biomarkers available through Tempus sequencing

Advanced analytical tech

Leverage AI- and ML-based analytical tools to unlock actionable insights

Immune Profile Score (IPS)

First-of-its-kind  biomarker utilizing DNA and RNA to prognosticate ICI response

Insights delivered with every sample

Assess key aspects of the tumor microenvironment (TME) and understand resistance mechanisms using standard and novel biomarker data. Tempus IO data is included with applicable next-generation sequencing (NGS) assay orders to ensure comprehensive insights without the need for additional sample collection.

Download the Tempus IO overview to learn more

  • Tempus xT: Solid Tumor DNA Seq

    Tumor Mutational Burden (TMB)

    Microsatellite Instability (MSI)

    Neoantigen Prediction

    Human Leukocyte Antigen (HLA) Typing

    HLA Loss of Heterozygosity (LOH)

    Oncogenic Virus

    Mismatch Repair (MMR) Proteins by IHC1

    PD-L1 Protein quantification by IHC1

    Mechanisms of Tumor Resistance to Immunotherapy2

    Immune Profile Score (IPS): ICI response prognosticator (available with concurrent xT and xR orders)

  • Tempus xE: Whole Exome

    Tumor Mutational Burden (TMB)

    Microsatellite Instability (MSI)

    Neoantigen Prediction

    Human Leukocyte Antigen (HLA) Typing

    Oncogenic Virus

    Mismatch Repair (MMR) Proteins by IHC1

    PD-L1 Protein quantification by IHC1

    Mechanisms of Tumor Resistance to Immunotherapy2

  • Tempus xR: Whole Transcriptome RNA Seq

    Gene Expression Target Profiling3

    Neoantigen Prediction

    Immune Infiltration

    Oncogenic Virus

    T-cell Receptor / B-cell Receptor Repertoire

    Mismatch Repair (MMR) Proteins by IHC1

    PD-L1 Protein quantification by IHC1

    Immune Profile Score (IPS): ICI response prognosticator (available with concurrent xT and xR orders)

  • Tempus xF/xF+: Liquid Biopsies

    Blood Tumor Mutational Burden (bTMB) (xF+ only)

    Microsatellite Instability (MSI) high status (xF/xF+)

Tumor Mutational Burden (TMB)

Microsatellite Instability (MSI)

Neoantigen Prediction

Human Leukocyte Antigen (HLA) Typing

HLA Loss of Heterozygosity (LOH)

Oncogenic Virus

Mismatch Repair (MMR) Proteins by IHC1

PD-L1 Protein quantification by IHC1

Mechanisms of Tumor Resistance to Immunotherapy2

Immune Profile Score (IPS): ICI response prognosticator (available with concurrent xT and xR orders)

Tumor Mutational Burden (TMB)

Microsatellite Instability (MSI)

Neoantigen Prediction

Human Leukocyte Antigen (HLA) Typing

Oncogenic Virus

Mismatch Repair (MMR) Proteins by IHC1

PD-L1 Protein quantification by IHC1

Mechanisms of Tumor Resistance to Immunotherapy2

Gene Expression Target Profiling3

Neoantigen Prediction

Immune Infiltration

Oncogenic Virus

T-cell Receptor / B-cell Receptor Repertoire

Mismatch Repair (MMR) Proteins by IHC1

PD-L1 Protein quantification by IHC1

Immune Profile Score (IPS): ICI response prognosticator (available with concurrent xT and xR orders)

Blood Tumor Mutational Burden (bTMB) (xF+ only)

Microsatellite Instability (MSI) high status (xF/xF+)

Go beyond sequencing with powerful analytics

Tempus’ analytical capabilities leverage AI and machine learning to enhance sequencing data, enabling the identification of potential biomarkers that correlate with therapy response. Our proprietary tools uncover novel cancer dependencies and drug targets, particularly in IO-resistant populations. Tempus also offers supplementary data, custom analyses, and specialized algorithms as add-ons to meet your specific research objectives.4

Discover Tempus Lens for in-depth data and insights
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Understand ICI treatment response

Utilize Tempus’ Immune Profile Score (IPS), a first-of-its-kind multimodal algorithm that uses DNA and RNA to provide prognostic insights into potential outcomes following immune checkpoint inhibitor (ICI) treatment in metastatic solid tumors.

The algorithm generates a score that categorizes study participants into:

  • IPS-High: Indicates a higher likelihood of favorable outcomes with ICI treatment.
  • IPS-Low: Indicates a lower likelihood of favorable outcomes with ICI treatment.
Learn more about Immune Profile Score (IPS)
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Powering clinical development with data and technology

Tempus operates CAP-accredited, CLIA-certified robotic sequencing labs in Chicago, Atlanta, and Raleigh with automated bioinformatics and variant classification reporting. Sequencing is typically completed within a median of 8 days after receiving samples.

Download our lab overview
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Our Science

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  • UPCOMING WEBINAR:

    Advancing IO therapeutics: The convergence of novel biomarkers and combination strategies

    This webinar highlights on the role of novel biomarkers and combination treatment strategies in understanding and enhancing the immune system's response to cancer. Discover the significant developments that are helping to shape clinical trials and improving patient outcomes in IO and hear perspectives from industry experts on the potential of emerging therapies.

    Watch replay
  • UPCOMING WEBINAR:

    The future of immuno-oncology research: Challenges, innovations, and the role of data-driven solutions

    This white paper offers an in-depth look at immuno-oncology (IO) research, emphasizing how data-driven research propels therapy development and enhances treatment efficacy. Download for a comprehensive analysis of the IO landscape, its projected market growth, and insights regarding pharmaceutical companies' strategic approaches to optimize therapeutic outcomes.

    Read now
  • UPCOMING WEBINAR:

    Q&A: A deep dive into the science and significance of Tempus’ Immune Profile Score (IPS)

    In this Q&A, Dr. Michelle Ting-Lin, Medical Director of Clinical Development at Tempus, provides insights into the science behind the Immune Profile Score (IPS), a novel biomarker designed to enhance the identification of patients who may benefit from immune checkpoint inhibitor (ICI) therapies.

    Read now
  • UPCOMING WEBINAR:

    Revolutionizing drug screening with Tempus AI's advanced imaging capabilities

    Learn how Tempus AI's noninvasive imaging techniques allow for the continuous study of the same organoids across various assays, preserving their viability for longitudinal analysis and multiplexed testing.

    Read now
  1. Assessment of MMR proteins by IHC, including MLH1, MSH2, MSH6, and PMS2, as well as PD-L1 IHC, is available as an optional add-on for Tempus xT/xE orders. This service is not automatically included in every order and should be selected by the customer.
  2. Tempus provides information on multiple variants and features that have been reported to confer resistance to immunotherapy. This includes mutations and/or copy number alterations in immune-associated genes that affect antigen presentation or interferon signaling. (xT, xE only)
  3. Tempus performs RNA whole transcriptome sequencing when sufficient tissue samples are provided.
  4. The availability of supplementary data is dependent on the scope of the request.

Partner with us

With a broad range of laboratory services and data analysis that support immunotherapy development, Tempus has the solutions you need.